CDNA 2
AMD Instinct MI250X
wins
1
The AMD Instinct MI250X is AMD's CDNA 2 data center GPU.
Blackwell
NVIDIA B300 192GB
wins
4
The NVIDIA B300 is the next step in the Blackwell lineup.
Performance comparison
Visual bars — winner highlighted
AMD Instinct MI250X
Metric
NVIDIA B300 192GB
FP16 TFLOPS
Bandwidth
VRAM
TDP (lower=better)
TFLOPS/watt
GB/s per watt
Full specification table
| Spec | AMD Instinct MI250X | NVIDIA B300 192GB |
|---|---|---|
| Architecture | CDNA 2 | Blackwell |
| VRAM | 128 GB HBM2e | 192 GB HBM3e |
| VRAM type | HBM2e | HBM3e |
| Memory bandwidth | 3,277 GB/s | 8,000 GB/s |
| FP16 TFLOPS | 383 TFLOPS | 5,000 TFLOPS |
| TDP | 560 W | 1,000 W |
| TFLOPS/watt | 0.68 T/W | 5.00 T/W |
| GB/s per watt | 5.85 GB/s/W | 8.00 GB/s/W |
| NVLink | No | Yes |
| Release year | 2021 | 2025 |
Live cloud pricing
On-demand pricing across providers — updated in real time
Power efficiency analysis
TFLOPS/watt and GB/s/watt — critical for data center TCO
AMD Instinct MI250X
NVIDIA B300 192GB
TFLOPS/watt measures compute efficiency — how much AI throughput you get per watt of power consumed. For data centers with PUE of 1.2–1.5, a 10% improvement in TFLOPS/watt translates directly to lower electricity costs and cooling requirements. GB/s/watt measures memory bandwidth efficiency, which is the binding constraint for memory-bound LLM inference workloads.
When to choose each GPU
Choose AMD Instinct MI250X for:
- HPC workloads
- Large model inference
- AMD ROCm deployments
Weaknesses / Limitations
- Older CDNA 2 architecture — lower FP16 TFLOPS than MI300X or H100
- ROCm software ecosystem less mature than CUDA
- 560W TDP — high power draw for its performance tier
Choose NVIDIA B300 192GB for:
- Next-gen LLM training
- Agent inference at scale
- Memory-intensive AI
Weaknesses / Limitations
- Very limited availability — not yet widely deployed on cloud platforms
- 1,000W TDP requires specialized power and cooling
- Premium pricing over B200 with incremental gains
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